The truck platooning is progressing since many years and addresses many major challenges of the long distance road freight transport: emission/decarbonisation, logistics chain improvement, road safety and infrastructure capacity. The emerging technologies of cooperative and automated vehicles are used. However, some pending issues remain under investigation: user acceptance, impact on traffic and infrastructure, operation and business models. The full implementation requires actions of all the stakeholders, technologies providers, OEMs, roads operators, designers and construction companies, as well as regulators and public authorities. Three keynote speakers will briefly introduce the main lessons learned from case studies and planned experiences in the EU member states and the US. A debate between panellists and the audience will deal with the next challenges of truck platooning, the implementation issues, the benefits assessment, and the combination of different approaches of connected vehicles. .